Not an actual patient.
Getting started
The recommended starting dose is two 100-mg capsules, which are taken twice each day—with or without food.
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In the clinical study, most people started and stayed on the same VONJO dose throughout treatment. 12% of patients taking VONJO had their dose reduced due to adverse events compared to 7% on best available therapy.
Remember:
- VONJO capsules should be swallowed whole, not chewed, opened, or broken into smaller pieces
- You should take VONJO at the same time every day
- Do not change your dose or stop taking VONJO without talking with your doctor
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Following your doctor’s prescription from the start is an important part of your VONJO daily treatment plan. Everyone has a different response to their treatment, and your doctor will see how you react to VONJO.
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If you miss a dose of VONJO, skip the dose and just take your next dose at your regularly scheduled time. Do not take 2 doses at the same time to make up for the missed dose.
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If you take another medicine for your MF, be sure to follow your doctor's instructions on how to slowly decrease (taper) your dose or stop taking it before you begin taking VONJO.
There are possible side effects you may need to watch for when taking VONJO
You can learn about the most common side effects that people taking VONJO experienced in a study here, or you can explore the Important Safety Information for VONJO below.
What to do if you experience diarrhea
If you notice a change in bowel movements or if they become softer, it may help to do the following:
Diarrhea is common with VONJO and can be severe. It will typically decrease over time. In the clinical study, it went away in 2 weeks. It’s important to talk to your doctor if your diarrhea gets worse or doesn't go away.
Tell your doctor right away if you:
- Experience unusual bleeding, bruising, and fever
- Feel dizzy, lightheaded, faint, or feel palpitations
- Notice any signs or symptoms of a blood clot—these include swelling, pain, or tenderness in one or both legs; sudden and unexplained chest pain; or shortness of breath or difficulty breathing
- Develop signs and symptoms of an infection—these include chills, nausea, vomiting, aches, weakness, fever, painful skin rash, or blisters
Get emergency help right away if you have any symptoms of a heart attack or stroke while taking VONJO, including:
- Discomfort in the center of your chest that lasts for more than a few minutes or that goes away and comes back
- Severe tightness, pain, pressure, or heaviness in your chest, throat, neck, or jaw
- Pain or discomfort in your arms, back, neck, jaw, or stomach
- Shortness of breath with or without chest discomfort
- Breaking out in a cold sweat
- Nausea or vomiting
- Lightheadedness
- Weakness in one part or on one side of your body
- Slurred speech
These are not all the side effects that could happen with VONJO. Please see the Important Safety Information below. Call your doctor if you have any questions or concerns.
Before you start taking VONJO, here’s what you need to know
Your doctor will run some tests before and during treatment with VONJO.
A complete blood count (CBC) helps track how you’re responding to treatment and if there are changes in your blood cell counts.
Coagulation testing will see how your blood is clotting and check your risk of bleeding before you start taking VONJO.
A baseline electrocardiogram (ECG) will check how your heart is working.
Don’t forget to tell your doctor about the medicines you’re taking (both prescription and over-the-counter medicines). You should also tell your doctor about all your medical conditions, including if you:
- Smoke or were a smoker in the past
- Have had any other cancers
- Have had a blood clot, heart attack, other heart problems, or stroke
- Have an infection
- Have diarrhea or commonly have loose stools
- Have nausea or vomiting
- Have liver or kidney problems
- Have active bleeding, have had severe bleeding, or plan to have surgery. You should stop taking VONJO 7 days before any planned surgery or invasive procedures (such as heart catheterization, stent placement in a coronary artery in your heart, or a procedure for varicose veins) because you may be at higher risk for bleeding
- Are pregnant or plan to become pregnant. You should not breastfeed during treatment or for 2 weeks after your last dose
- Plan to father a child—VONJO may affect fertility in males
